Data/hora: 10/06/2024 06:32:14

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	High susceptibility of activated lymphocytes to oxidative stress-induced cell death	
Autores: 	Degasperi,Giovanna R.; Castilho,Roger F.; Vercesi,Anibal E.	
Data: 	2008-03-01	
Ano: 	2008	
Palavras-chave: 	Cell death; Free radicals; Immune response; Lymphopenia; Mitochondrial permeability transition; Spleen lymphocyte.	
Resumo: 	The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin A, but not the calcineurin inhibitor FK-506, render control and activated lymphocytes equally resistant to the toxic effects of t-BOOH. Incubation of activated lymphocytes in the presence of t-BOOH resulted in a cyclosporin A-sensitive decrease in mitochondrial membrane potential. These results indicate that the higher cytosolic Ca2+ level in activated lymphocytes increases their susceptibility to oxidative stress-induced cell death in a mechanism involving the participation of mitochondrial permeability transition.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100009	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652008000100009	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.80 n.1 2008	
Fonte: 	info:eu-repo/semantics/openAccess