Data/hora: 04/06/2024 12:33:41

Provedor de dados: | 42
País: | Brazil
Título: | CYP2B6 516 G&amp;gt;T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Autores: | MÜLLER,TALISE E.; ELLWANGER,JOEL H.; MICHITA,RAFAEL T.; MATTE,MARIA CRISTINA C.; RENNER,JANE D.P.
Data: | 2017-05-01
Ano: | 2017
Palavras-chave: | HIV; Efavirenz; Antiretroviral therapy; CYP2B6.
Resumo: | ABSTRACT This study aimed to identify the 516 G&gt;T polymorphism of the CYP2B6 gene and evaluate its influence on central nervous system (CNS) side effect development in HIV-positive individuals undergoing Efavirenz (EFV) treatment in a population from southern Brazil. Additionally, we performed a survey on the clinical and epidemiological characteristics of our sample. In addition to medical records evaluation, whole blood of 89 individuals was analyzed for viral load, T lymphocyte count (CD4+ and CD8+), and the polymorphism. Considering the side effects of the CNS reported by individuals but without considering the genetic variables, no statistically significant association was noted between the adverse effects and the antiretroviral treatment (including or not EFV). In addition, no statistically significant difference was noted for the influence of genotype on the viral load or the number of T lymphocytes (CD4+ and CD8+) among individuals undergoing EFV treatment. This is the first study that investigated the impact of the 516 G&gt;T polymorphism of the CYP2B6 gene among HIV-positive individuals from southern Brazil. Its clinical significance indicates the need for prospective studies in this population.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200497
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720160355
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.1 suppl.0 2017
Fonte: | info:eu-repo/semantics/openAccess