Data/hora: 03/06/2024 02:43:46

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado	
Autores: 	MOREIRA,RAQUEL R.D.; MARTINS,GILMARCIO Z.; MAGALHÃES,NATHÁLIA O.; ALMEIDA,ADÉLIA E.; PIETRO,ROSEMEIRE C.L.R.; SILVA,FLÁVIA A. J.; CICARELLI,REGINA M.B.	
Data: 	2013-09-01	
Ano: 	2013	
Palavras-chave: 	Solanum palinacanthum; Solanum lycocarpum; Solamargine; Epimastigote; Antitrypanosomal activity; Trypanosoma cruzi.	
Resumo: 	The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S. lycocarpum fruit powders were submitted to exhaustively extraction with 96% ethanol and solamargine were isolated from the extract of S. palinacanthum. Both extracts and solamargine were analysed for trypanocidal activity by using MTT colorimetric assay. Extracts of S. palinacanthum showed to be more active (IC50 = 175.9 µg.ml–1) than S. lycocarpum (IC50 = 194.7 µg.ml–1). Solamargine presented a strong activity (IC50 = 15.3 µg.ml–1), which can explain the better activity of the both extracts. Benznidazol (IC50 = 9.0 µg.ml–1) is the only drug used to treat Chagas' disease. These findings demonstrate for the first time that ethanol extracts obtained from both fruits of S. palinacanthum and S. lycocarpum and also solamargine have a potential anti-trypanosomal activity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300903	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652013000300006	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.85 n.3 2013	
Fonte: 	info:eu-repo/semantics/openAccess