Data/hora: 12/06/2024 15:30:42

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.	
Autores: 	BARROS,BÁRBARA R.S.; BARBOZA,BRUNO RAFAEL; RAMOS,BÁRBARA A.; MOURA,MAIARA C. DE; COELHO,LUANA C.B.B.; NAPOLEÃO,THIAGO HENRIQUE; CORREIA,MARIA TEREZA S.; PAIVA,PATRÍCIA MARIA G.; CRUZ FILHO,IRANILDO JOSÉ DA; SILVA,TÚLIO DIEGO DA; LIMA,CLÁUDIA S.A.; MELO,CRISTIANE M.L. DE.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Bioactive compounds; Cytotoxicity; Malpighia emarginata DC; Phytochemical.	
Resumo: 	Abstract: Currently, the research of new natural compounds with biological potential demonstrates great ethnopharmacological importance. In this study, we evaluated the biological properties promoted by saline extract from Malpighia emarginata DC leaves, whose objective is to evaluate the antioxidant, antimicrobial and cytotoxicity potential. Phytochemical characterization was performed by UPLC-MS chromatography to identify the chemical compounds. For the antioxidant potential, DPPH, ATT and FRAP methods were used. The antibacterial and antifungal tests were performed evaluating the MIC50, MIC90, CMB and CMF parameters. Moreover, antibiofilm action was evaluated. Cytotoxicity and proliferation were performed using splenocytes from Balb/c mice and were evaluated by cytometry. We found a list of phenolic compounds among other bioactive compounds in the M. emarginata saline extract. In addition, higher antioxidant profile and antifungal activity against different strains of Candida spp. was promoted by the saline extract. Splenocytes showed greater cell viability (more than 90%) and showed higher proliferate index in 24 and 48 hours of incubation with the extract. Saline extract from Malpighia emarginata DC has potential action like antioxidant and antifungal agent without promote animal cell damage.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100627	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201920180358	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.91 n.1 2019	
Fonte: 	info:eu-repo/semantics/openAccess