Data/hora: 08/06/2024 08:42:15

Provedor de dados: | 42
País: | Brazil
Título: | Consequences of gestational diabetes to the brain and behavior of the offspring
Autores: | SOUSA,RICARDO A.L. DE; TORRES,YASMIN S.; FIGUEIREDO,CLAUDIA P.; PASSOS,GISELLE F.; CLARKE,JULIA R.
Data: | 2018-08-01
Ano: | 2018
Palavras-chave: | Insulin resistance; Hippocampus; Inflammation; Depression; Learning; Memory; Programing.
Resumo: | ABSTRACT Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show this condition. For many years, the transient nature of GD has led researchers and physicians to assume that long-term consequences were absent. However, GD diagnosis leads to a six-fold increase in the risk of developing type 2 diabetes (T2D) in women and incidence of obesity and T2D is also higher among their infants. Recent and concerning evidences point to detrimental effects of GD on the behavior and cognition of the offspring, which often persist until adolescence or adulthood. Considering that the perinatal period is critical for determination of adult behavior, it is expected that the intra-uterine exposure to hyperglycemia, hyperinsulinemia and pro-inflammatory mediators, hallmark features of GD, might affect brain development. Here, we review early clinical and experimental evidence linking GD to consequences on the behavior of the offspring, focusing on memory and mood disorders. We also discuss initial evidence suggesting that downregulation of insulin signaling cascades are seen in the brains of GD offspring and could contribute to the consequences on their behavior.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502279
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720170264
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.2 suppl.1 2018
Fonte: | info:eu-repo/semantics/openAccess