Data/hora: 16/06/2024 20:42:20

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster	
Autores: 	FRANCHI,LEONARDO P.; GUIMARAES,NILZA N.; ANDRADE,LAISE R. DE; ANDRADE,HELOISA H.R. DE; LEHMANN,MAURICIO; DIHL,RAFAEL R.; CUNHA,KENYA S.	
Data: 	2013-06-01	
Ano: 	2013	
Palavras-chave: 	Antigenotoxicity; Doxorrubicin; Mitomycin C; SMART; Noni juice.	
Resumo: 	Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3      ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652013000200008	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.85 n.2 2013	
Fonte: 	info:eu-repo/semantics/openAccess