Data/hora: 10/06/2024 06:36:11

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Molecular epidemiology of 16S rRNA methyltransferase in Brazil: RmtG in Klebsiella aerogenes ST93 (CC4)	
Autores: 	PASSARELLI-ARAUJO,HEMANOEL; PALMEIRO,JUSSARA K.; MOHARANA,KANHU C.; PEDROSA-SILVA,FRANCISNEI; DALLA-COSTA,LIBERA M.; VENANCIO,THIAGO M.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Klebsiella aerogenes; Aminoglycoside; 16S rRNA methyltransferases; Multidrug resistance.	
Resumo: 	Abstract Aminoglycosides are a class of antibiotics that play a key role in antimicrobial treatment of Multidrug resistant (MDR) Gram-negative bacilli, typically in combination with β-lactams. Ribosomal 16S RNA modification by methyltransferases (e.g. RmtG) is an aminoglycoside resistance mechanism that, along with the occurrence carbapenem-resistant Enterobacteriaceae (CRE), has become a clinical concern. In Brazil, rmtG genes were initially reported in Klebsiella pneumoniae, and monitoring isolates from other species carrying this gene is critical for epidemiological studies and to prevent dissemination. Here we report the presence of rmtG in Klebisella aerogenes D3 and characterize its genetic context in comparison to isolates from other species. Further, we performed a phylogenetic reconstruction of 900 16S rRNA methyltransferases (16S-RMTases) and methyltransferase-related proteins. We show that, in K. aerogenes D3, rmtG co-occurs with sul2, near a transposon with an IS91-like insertion sequence. Resistome analysis revealed the co-production of RmtG and CTX-M-59. Ongoing surveillance of 16S-RMTases is crucial to delay the dissemination of such multiresistant isolates. Our results also highlight the reduction in treatment options for CRE infections, as well as the need of expanding prevention measures of these pathogens worldwide.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000200602	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-376520182018762	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.91 suppl.1 2019	
Fonte: 	info:eu-repo/semantics/openAccess