Data/hora: 02/06/2024 07:32:58

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Hematological and biochemical profile of BALB/c nude and C57BL/6 SCID female mice after ovarian xenograft	
Autores: 	FERNANDES,DENILSA P.; PIMENTEL,MURIEL M.L.; SANTOS,FERNANDA A. DOS; PRAXEDES,ÉRIKA A.; BRITO,PARMÊNEDES D. DE; LIMA,MIKAEL A.; LELIS,IVANA C.N.G.; MACEDO,MICHELLY F. DE; BEZERRA,MARCELO B.	
Data: 	2018-12-01	
Ano: 	2018	
Palavras-chave: 	Biochemistry; Hematology; Immunosuppressed; Mus musculus.	
Resumo: 	Abstract Hematological and biochemical profile studies help to evaluate functional changes of animals used in experiments. The aim of this study was to determine the hematological and biochemical profile of immunosuppressed BALB/c nude and C57BL/6 SCID mice after bovine ovarian xenotransplantation. Therefore, a total of 74 female mice were divided into four groups: non-xenotransplanted animals, xenotransplanted animals, xenotransplanted animals treated with eCG and xenotransplanted animals treated with FSH + LH. After anesthesia, blood samples were collected and hematologic and biochemical values were evaluated. The results showed no significant differences (p ≤ 0.05) for hematological parameters between the control group and the treatment groups of both strains. However, considering the biochemical profile, it was observed an increase of AST concentrations (p ≤ 0.05) in both strains and a decrease of ALT concentrations (p ≤ 0.05) only in C57BL/6 SCID strain of the groups subjected to hormonal treatment compared with those non subjected. Additionally, the values of the renal enzymes, urea and creatinine, did not differ (p ≤ 0.05) between the groups. Our findings suggest that the xenotransplantation procedure as well as the hormonal dosages had no significant effect on the well-being of the animals considering the evaluated hematological and biochemical profile.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000703941	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201820180586	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.90 n.4 2018	
Fonte: 	info:eu-repo/semantics/openAccess