Data/hora: 01/06/2024 16:51:58

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Short and long period optimization of drug doses in the treatment of AIDS	
Autores: 	CAETANO,MARCO A. L.; YONEYAMA,TAKASHI.	
Data: 	2002-09-01	
Ano: 	2002	
Palavras-chave: 	Modeling; Simulation; Drugs; Treatment; AIDS.	
Resumo: 	Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a series and the sub-optimal control is obtained by truncating the higher terms. When the patient reaches a clinically satisfactory state, the LQR - Linear Quadratic Regulator technique is used to determine the long period maintenance doses for the drugs. The doses computed using the LQR technique tend to be smaller than equivalent constant-dose therapy in terms of increase in the counts of CD4+T cells and reduction of the density of free viruses.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300002	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652002000300002	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.74 n.3 2002	
Fonte: 	info:eu-repo/semantics/openAccess