Data/hora: 06/06/2024 00:25:23

Provedor de dados: | 42
País: | Brazil
Título: | Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
Autores: | HERRERA,KARINA M.S.; FERREIRA,LORENA S.; BRAGA,ALYSSON V.; SOUZA,JULIANO P.; ANDRADE,JÉSSICA T.; SOARES,ADRIANA C.; SOARES,LUIS F.; CHAGAS,RAFAEL C.R.; FERREIRA,JAQUELINE M.S.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | 1; 2-bis-bis (2-thiazolin-2-isulfanyl) ethane antimicrobial activity hidrotris (2-mercaptothiazolyl) borate complexes.
Resumo: | Abstract: Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700803
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-376520181077
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.91 n.4 2019
Fonte: | info:eu-repo/semantics/openAccess