Data/hora: 03/06/2024 05:36:11

Provedor de dados: | Anais da Academia Brasileira de Ciências
País: | Brazil
Título: | A structural perspective on the mechanisms of quorum sensing activation in bacteria
Autores: | LIXA,CAROLINA; MUJO,AMANDA; ANOBOM,CRISTIANE D.; PINHEIRO,ANDERSON S.
Data: | 2015-12-01
Ano: | 2015
Palavras-chave: | Autoinducer; Bacteria; Quorum sensing; Receptor; Structure.
Resumo: | Bacteria are able to synchronize the population behavior in order to regulate gene expression through a cell-to-cell communication mechanism called quorum sensing. This phenomenon involves the production, detection and the response to extracellular signaling molecules named autoinducers, which directly or indirectly regulate gene expression in a cell density-dependent manner. Quorum sensing may control a wide range of biological processes in bacteria, such as bioluminescence, virulence factor production, biofilm formation and antibiotic resistance. The autoinducers are recognized by specific receptors that can either be membrane-bound histidine kinase receptors, which work by activating cognate cytoplasmic response regulators, or cytoplasmic receptors acting as transcription factors. In this review, we focused on the cytosolic quorum sensing regulators whose three-dimensional structures helped elucidate their mechanisms of action. Structural studies of quorum sensing receptors may enable the rational design of inhibitor molecules. Ultimately, this approach may represent an effective alternative to treat infections where classical antimicrobial therapy fails to overcome the microorganism virulence.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000502189
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201520140482
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.87 n.4 2015
Fonte: | info:eu-repo/semantics/openAccess