Data/hora: 11/06/2024 04:17:59

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of  Myrciaria floribunda	
Autores: 	TIETBOHL,LUIS A.C.; OLIVEIRA,ADRIANA P.; ESTEVES,RICARDO S.; ALBUQUERQUE,RICARDO D.D.G.; FOLLY,DIOGO; MACHADO,FRANCISCO P.; CORRÊA,ARTHUR L.; SANTOS,MARCELO G.; RUIZ,ANA L.G.; ROCHA,LEANDRO.	
Data: 	2017-06-01	
Ano: 	2017	
Palavras-chave: 	Antiproliferative; Flavonoids; Myrciaria floribunda; Phenols.	
Resumo: 	ABSTRACT Myrciaria floribunda (H. West ex Willd.) O. Berg, Myrtaceae, is a native plant species of the Atlantic Rain Forest, from north to south of Brazil. The lyophilized ethyl acetate extract from the leaves of M. floribunda was investigated for its antiproliferative activity in tumor cell lines, antioxidant capacity and its total phenolic, flavonoid and tannin contents. Antiproliferative activity was tested in vitro against seven human cancer cells and against immortalized human skin keratinocytes line (HaCat, no cancer cell). Antioxidant activity was determined using 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and oxygen radical absorbing capacity (ORAC) assays and total phenolic, flavonoid and tannin contents were determined by spectrophotometric techniques. Ethyl acetate extract of M. floribunda exhibited antiproliferative activity against cancer cell lines with total growth inhibition (TGI) between 69.70 and 172.10 µg/mL. For HaCat cell, TGI value was 213.60 µg/mL. M. floribunda showed a strong antioxidant potential: EC50 of 45.89±0.42 µg/mL and 0.55±0.05 mmol TE/g for DPPH and ORAC, respectively. Total phenolic content was 0.23±0.013g gallic acid equivalents (GAE)/g extract and exhibited 13.10±1.60% of tannins content. The content of flavonoid was 24.08±0.44% expressed as rutin equivalents. These results provide a direction for further researches about the antitumoral potential of M. floribunda.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301111	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720160461	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess