Data/hora: 11/06/2024 11:14:36

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk	
Autores: 	COSTA-SILVA,DANYLO R.; BARROS-OLIVEIRA,MARIA DA CONCEIÇÃO; BORGES,RAFAEL S.; TAVARES,CLÉCITON B.; BORGES,UMBELINA S.; ALVES-RIBEIRO,FRANCISCO A.; SILVA,VLADIMIR C.; SILVA,BENEDITO B. DA.	
Data: 	2016-12-01	
Ano: 	2016	
Palavras-chave: 	Breast cancer; Risk factors; IGF-1; IGF-1 gene polymorphism.	
Resumo: 	ABSTRACT Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602349	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201620160169	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.88 n.4 2016	
Fonte: 	info:eu-repo/semantics/openAccess