Data/hora: 04/06/2024 03:37:34

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress	
Autores: 	Zacks,Michele A.; Wen,Jian-Jun; Vyatkina,Galina; Bhatia,Vandanajay; Garg,Nisha.	
Data: 	2005-12-01	
Ano: 	2005	
Palavras-chave: 	Chagasic cardiomyopathy; Reactive oxygen species; Inflammation; Mitochondria; Oxidant/antioxidant status; Oxidative damage.	
Resumo: 	There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role of oxidative stress in chagasic cardiomyopathy (CCM) remains incomplete. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, electron transport chain dysfunction and its role in sustaining oxidative stress in myocardium. We discuss the literature reporting the consequences of sustained oxidative stress in CCM pathogenesis.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000400009	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652005000400009	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.77 n.4 2005	
Fonte: 	info:eu-repo/semantics/openAccess