Data/hora: 04/06/2024 05:33:36

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils	
Autores: 	PINTO,MARIA E.A.; ARAÚJO,STHÉFANE G.; MORAIS,MARCELA I.; SÁ,NÍVEA P.; LIMA,CAROLINE M.; ROSA,CARLOS A.; SIQUEIRA,EZEQUIAS P.; JOHANN,SUSANA; LIMA,LUCIANA A.R.S.	
Data: 	2017-09-01	
Ano: 	2017	
Palavras-chave: 	Antifungal; Antioxidant; Fatty acid methyl esters; Vegetable oils.	
Resumo: 	ABSTRACT Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401671	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720160908	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.3 2017	
Fonte: 	info:eu-repo/semantics/openAccess