Data/hora: 02/06/2024 17:21:55

Provedor de dados: | 42
País: | Brazil
Título: | The specificity of interactions between proteins and sulfated polysaccharides
Autores: | Mulloy,Barbara.
Data: | 2005-12-01
Ano: | 2005
Palavras-chave: | Sulfated polysaccharides; Fucans; Dermatan sulfate; Heparan sulfate; Heparin; Protein structure; Growth factors; Development.
Resumo: | Sulfated polysaccharides are capable of binding with proteins at several levels of specificity. As highly acidic macromolecules, they can bind non-specifically to any basic patch on a protein surface at low ionic strength, and such interactions are not likely to be physiologically significant. On the other hand, several systems have been identified in which very specific substructures of sulfated polysaccharides confer high affinity for particular proteins; the best-known example of this is the pentasaccharide in heparin with high affinity for antithrombin, but other examples may be taken from the study of marine invertebrates: the importance of the fine structure of dermatan sulfate (DS) to its interaction with heparin cofactor II (HCII), and the involvement of sea urchin egg-jelly fucans in species specific fertilization. A third, intermediate, kind of specific interaction is described for the cell-surface glycosaminoglycan heparan sulfate (HS), in which patterns of sulfate substitution can show differential affinities for cytokines, growth factors, and morphogens at cell surfaces and in the intracellular matrix. This complex interplay of proteins and glycans is capable of influencing the diffusion of such proteins through tissue, as well as modulating cellular responses to them.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000400007
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652005000400007
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.77 n.4 2005
Fonte: | info:eu-repo/semantics/openAccess