Data/hora: 11/06/2024 10:15:52

Provedor de dados: | 42
País: | Brazil
Título: | Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
Autores: | Nabavi,Seyed M.; Nabavi,Seyed F.; Moghaddam,Akbar H.; Setzer,William N.; Mirzaei,Morteza.
Data: | 2012-12-01
Ano: | 2012
Palavras-chave: | Catalase; Glutathione; Sodium fluoride; Superoxide dismutase; Silymarin; TBARS.
Resumo: | This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652012005000056
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.84 n.4 2012
Fonte: | info:eu-repo/semantics/openAccess