Data/hora: 16/06/2024 06:38:05

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues	
Autores: 	Nabavi,Seyed M.; Nabavi,Seyed F.; Moghaddam,Akbar H.; Setzer,William N.; Mirzaei,Morteza.	
Data: 	2012-12-01	
Ano: 	2012	
Palavras-chave: 	Catalase; Glutathione; Sodium fluoride; Superoxide dismutase; Silymarin; TBARS.	
Resumo: 	This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652012005000056	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.84 n.4 2012	
Fonte: 	info:eu-repo/semantics/openAccess