Data/hora: 01/06/2024 02:35:04

Provedor de dados: | Anais da Academia Brasileira de Ciências
País: | Brazil
Título: | Antifungal activity of the extracts and saponins from Sapindus saponaria L.
Autores: | Tsuzuki,Joyce K.; Svidzinski,Terezinha I.E.; Shinobu,Cristiane S.; Silva,Luiz F.A.; Rodrigues-Filho,Edson; Cortez,Diógenes A.G.; Ferreira,Izabel C.P.
Data: | 2007-12-01
Ano: | 2007
Palavras-chave: | Sapindaceae; Sapindus saponaria; Saponins; Antifungal activity; Candida.
Resumo: | Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1-&gt;3)-alpha-Lrhamnopyranosyl-(1-&gt;2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1-&gt;3)-alpha-L-rhamnopyranosyl-(1-&gt;2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data (¹H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400002
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652007000400002
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.79 n.4 2007
Fonte: | info:eu-repo/semantics/openAccess