Data/hora: 05/06/2024 09:09:24

Provedor de dados: | 42
País: | Brazil
Título: | Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells
Autores: | BELLE,MONICA B.B.; LEFFA,DANIELA D.; MAZZORANA,DALIANE; ANDRADE,VANESSA M. DE.
Data: | 2013-06-01
Ano: | 2013
Palavras-chave: | Chromosomes; Contrast medium; Micronuclei; Urografina® 292.
Resumo: | Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in vivo. Micronuclei assay was performed in BMC of CF-1 mice injected with CM 1.5 and 3.0 mL/kg intravenous doses and 1.0, 2.0, 3.0 mL/kg intraperitoneal doses. The animals were beheaded 24 h after treatment by cervical dislocation, and femur BMC from each animal were used in the micronucleus test. The group treated with the highest intravenous injection of Urografina® 292 (3.0 mL/kg) presented an increase in the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in relation at the control group (P&lt;0.05). The results obtained after intraperitoneal administration of CM showed that all doses (1.0 mL/kg, 2.0 mL/kg and 3.0 mL/kg) increased the frequency of MNPCEs, being significantly different from the negative control (P&lt; 0.01). The present results suggest that iodinated contrast media Urografina® 292 may cause a significant increase of cytogenetic damage in bone marrow cells of mice.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200737
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652013000200018
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.85 n.2 2013
Fonte: | info:eu-repo/semantics/openAccess