Data/hora: 03/06/2024 18:31:00

Provedor de dados: 	42	
País: 	Brazil	
Título: 	A reassessment of the role of serotonergic system in the control of feeding behavior	
Autores: 	Medeiros,Magda A.; Costa-e-Sousa,Ricardo H.; Olivares,Emerson L.; Côrtes,Wellington S.; Reis,Luís C.	
Data: 	2005-03-01	
Ano: 	2005	
Palavras-chave: 	Food ingestion; Serotonergic system; Dorsal raphe nucleus; Electrolytic lesion; Para-chlorophenylalanine; Obesity.	
Resumo: 	The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In the acute study, the LHTP reverted partially the PCPA-induced increase in food intake of fasted rats suggesting a sustained capacity of decarboxylation of precursor by serotonergic neurons. Slow restoration of the levels of food intake in DRN-lesioned rats reveals a neuroplasticity in the systems that regulate feeding behavior. A plateau on the body weight curve in lesioned rats possibly represents the establishment of a new and higher set point of energetic balance.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652005000100008	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.77 n.1 2005	
Fonte: 	info:eu-repo/semantics/openAccess