Data/hora: 04/06/2024 04:34:18

Provedor de dados: | 42
País: | Brazil
Título: | A reassessment of the role of serotonergic system in the control of feeding behavior
Autores: | Medeiros,Magda A.; Costa-e-Sousa,Ricardo H.; Olivares,Emerson L.; Côrtes,Wellington S.; Reis,Luís C.
Data: | 2005-03-01
Ano: | 2005
Palavras-chave: | Food ingestion; Serotonergic system; Dorsal raphe nucleus; Electrolytic lesion; Para-chlorophenylalanine; Obesity.
Resumo: | The role of serotonergic system in the feeding behaviorwas appraised by electrolytic lesions in the dorsal raphe nucleus (DRN) and administration of para-chlorophenylalanine (PCPA, 3 mg/5 mul, icv). Chronic evaluations were accomplished through 120 and 360 days in PCPA-injected and DRN-lesioned rats, respectively. Acute food intake was evaluated in fasted rats and submitted to injection of PCPA and hydroxytryptophan (LHTP, 30 mg/kg, ip). DRN-lesioned rats exhibited 22-80% increase in food intake up to sixth month, whereas the obesity was evident and sustained by whole period. In PCPA-injected rats was observed an initial increase in the food intake followed by hypophagy from 25th to 30th day and a transitory increase of body weight from 5th to 60th day. In the acute study, the LHTP reverted partially the PCPA-induced increase in food intake of fasted rats suggesting a sustained capacity of decarboxylation of precursor by serotonergic neurons. Slow restoration of the levels of food intake in DRN-lesioned rats reveals a neuroplasticity in the systems that regulate feeding behavior. A plateau on the body weight curve in lesioned rats possibly represents the establishment of a new and higher set point of energetic balance.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100008
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652005000100008
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.77 n.1 2005
Fonte: | info:eu-repo/semantics/openAccess