Data/hora: 29/05/2024 01:27:58

Provedor de dados: | Anais da Academia Brasileira de Ciências
País: | Brazil
Título: | The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks
Autores: | Izquierdo,Iván; Cammarota,Martín; Silva,Weber C. Da; Bevilaqua,Lia R.M.; Rossato,Janine I.; Bonini,Juliana S.; Mello,Pamela; Benetti,Fernando; Costa,Jaderson C.; Medina,Jorge H.
Data: | 2008-03-01
Ano: | 2008
Palavras-chave: | Long-term potentiation; Hippocampus; Declarative memory; Aversive memory.
Resumo: | Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala, entorhinal cortex, parietal cortex) are also necessary for memory formation of the one-trial task, and perhaps of many others.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100007
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652008000100007
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.80 n.1 2008
Fonte: | info:eu-repo/semantics/openAccess