Data/hora: 16/06/2024 07:10:59

Provedor de dados: | 42
País: | Brazil
Título: | Recognition memory and DNA damage in undernourished young rats
Autores: | MOLZ,PATRÍCIA; ELLWANGER,JOEL H.; ZENKNER,FERNANDA F.; CAMPOS,DEIVIS DE; PRÁ,DANIEL; PUTZKE,MARISA T.L.; FRANKE,SILVIA I.R.
Data: | 2016-01-01
Ano: | 2016
Palavras-chave: | DNA damage; Memory; Nutritional status; Undernutrition; Wistar rats.
Resumo: | ABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage. Student t test, 2-way ANOVA and Pearson's correlation analysis were used and the significance level was of p&lt;0.05. The UG showed lower BMI and organ/tissue weights than CG (p&lt;0.001). In short-term memory, the recognition rate was higher in the UG (p&lt;0.05), only after 4 weeks. In the long-term memory, again recognition rate was higher in the UG than the CG, after 4 weeks (p&lt;0.001) and 14 weeks (p&lt;0.01). The UG showed decreased levels of DNA damage in the blood (p&lt;0.01) and increased levels in the hippocampus (p&lt;0.01). We concluded in this study that the undernutrition by caloric restriction did not cause impairment in recognition memory, however induced DNA damage in the hippocampus.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501863
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201620150608
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.88 n.3 suppl.0 2016
Fonte: | info:eu-repo/semantics/openAccess