Data/hora: 09/06/2024 13:39:08

Provedor de dados: | 42
País: | Brazil
Título: | Biflorin: an o-naphthoquinone of clinical significance
Autores: | WISINTAINER,GABRIELLE G.N.S.; SIMÕES,EVELYNE R.B.; LEMOS,TELMA L.G.; MOURA,SIDNEI; SOUZA,LUCIANA G.S.; FONSECA,ALUISIO M.; MORAES,MANOEL ODORICO; PESSOA,CLAUDIA; ROESCH-ELY,MARIANA; HENRIQUES,JOÃO A.P.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Biological activity; Biflorin; Capraria biflora; Natural products.
Resumo: | Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201420140085
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.86 n.4 2014
Fonte: | info:eu-repo/semantics/openAccess