Data/hora: 09/06/2024 11:53:27

Provedor de dados: | 42
País: | Brazil
Título: | Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables
Autores: | MONSALVE,BERNARDITA; CONCHA-MEYER,ANIBAL; PALOMO,IVÁN; FUENTES,EDUARDO.
Data: | 2017-05-01
Ano: | 2017
Palavras-chave: | Endothelium; Natural bioactive compounds; Polyphenols; Cardiovascular diseases.
Resumo: | ABSTRACT The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words: endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases. In this context, high intakes of fruit and vegetables are associated with the decrease of cardiovascular diseases. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In this article natural bioactive compound mechanisms of endothelium protection are thoroughly reviewed.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200615
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720160509
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.1 suppl.0 2017
Fonte: | info:eu-repo/semantics/openAccess