Data/hora: 10/06/2024 11:16:47

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Differential Effect of Solution Conditions on the Conformation of the Actinoporins Sticholysin II and Equinatoxin II	
Autores: 	FAUTH,EDSON V.F.; CILLI,EDUARDO M.; LIGABUE-BRAUN,RODRIGO; VERLI,HUGO.	
Data: 	2014-12-01	
Ano: 	2014	
Palavras-chave: 	Actinoporins; GROMACS; Molecular dynamics; Pore-forming proteins.	
Resumo: 	Actinoporins are a family of pore-forming proteins with hemolytic activity. The structural basis for such activity appears to depend on their correct folding. Such folding encompasses a phosphocholine binding site, a tryptophan-rich region and the activity-related N-terminus segment. Additionally, different solution conditions are known to be able to influence the pore formation by actinoporins, as for Sticholysin II (StnII) and Equinatoxin II (EqtxII). In this context, the current work intends to characterize the influence of distinct solution conditions in the conformational behavior of these proteins through molecular dynamics (MD) simulations. The obtained data offer structural insights into actinoporins dynamics in solution, characterizing its conformational behavior at the atomic level, in accordance with previous experimental data on StnII and EqtxII hemolytic activities.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401949	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201420140270	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.86 n.4 2014	
Fonte: 	info:eu-repo/semantics/openAccess