Data/hora: 08/06/2024 17:56:57

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease	
Autores: 	DEFELICE,FERNANDA G.; FERREIRA,SÉRGIO T.	
Data: 	2002-06-01	
Ano: 	2002	
Palavras-chave: 	Alzheimer's disease; Abeta peptide; Aggregation; Neurotoxicity; Physiopathological modulators.	
Resumo: 	The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652002000200006	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.74 n.2 2002	
Fonte: 	info:eu-repo/semantics/openAccess