Data/hora: 16/06/2024 09:43:00

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta	
Autores: 	MARTINEZ,JOSÉ L.; BENITES,JULIO; GOMEZ,HAROLD; VARGAS-RUEDA,SILVIA; VINET,RAÚL; JAIMES,LUISAURIS; LAURIDO,CLAUDIO.	
Data: 	2018-04-01	
Ano: 	2018	
Palavras-chave: 	Antioquine; Tetrandrine; Verapamil; Calcium antagonism; Rat thoracic aorta.	
Resumo: 	ABSTRACT The objective of this study was to compare two alkaloids (antioquine and tetrandrine) with verapamil; knowing that the smooth muscle respond to KCl and relationships with calcium. The effects of antioquine and tetrandrine, was studied in adults Wistar rat with modified methods used in the determination of aorta contractility and compared with verapamil effect in the same assays. The analysis of the effect of a drug or extract on aortic reactivity included maximal relaxation or maximal contraction (Cmax) (Phase 1). In our results, verapamil induced a blockade of 98.7 ± 0.7% (n = 6) in presence of endothelium and 97.9 ± 4.3% in ausence of endothelium, both in phase 1 and in phase 2 of 47.4 ± 4.1% (n = 6) in aortas in the presence of endothelium and 61.8 ± 1.1% in ausence of endothelium; Tetrandrine assays showed a phase 1 blocking effect of 63.4 ± 5.5 and 47.7 ± 2.9% (with and without endothelium, respectively) and phase 2 of 43.5 ± 6.2 and 28.5 ± 5.7%, (with and without endothelium, respectively). Antioquine presents in phase 1 and phase 2, a blockade that is not significant from the point of view of calcium antagonism. We can conclude that tetrandrine block the movement of calcium from both intracellular and extracellular deposits, with the greatest effect when aortas are in the presence of endothelium.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401459	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201820170608	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.90 n.2 2018	
Fonte: 	info:eu-repo/semantics/openAccess