Data/hora: 10/06/2024 18:01:55

Provedor de dados: | Anais da Academia Brasileira de Ciências
País: | Brazil
Título: | Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species
Autores: | OLIVEIRA JR,ALBERTO F.; FOLADOR,EDSON L.; GOMIDE,ANNE C.P.; GOES-NETO,ARISTÓTELES; AZEVEDO,VASCO A.C.; WATTAM,ALICE R.
Data: | 2018-08-01
Ano: | 2018
Palavras-chave: | Cell division; Corynebacterium; FtsZ; SepF; Molecular docking.
Resumo: | ABSTRACT The genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502179
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201820170385
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.2 suppl.1 2018
Fonte: | info:eu-repo/semantics/openAccess