Data/hora: 04/06/2024 12:22:23

Provedor de dados: | 42
País: | Brazil
Título: | Role of the serotoninergic system in the sodium appetite control
Autores: | Reis,Luís C.
Data: | 2007-06-01
Ano: | 2007
Palavras-chave: | Hydroelectrolyte balance; Sodium appetite; 5-HTergic system; Dorsal raphe nucleus; Lateral parabrachial nucleus; 5-HTergic agents.
Resumo: | The present article reviews the role of the serotoninergic system in the regulation of the sodium appetite. Data from the peripheral and icv administration of serotoninergic (5-HTergic) agents showed the participation of 5-HT2/3 receptors in the modulation of sodium appetite. These observations were extended with the studies carried out after brain serotonin depletion, lesions of DRN and during blockade of 5-HT2A/2C receptors in lateral parabrachial nucleus (LPBN). Brain serotonin depletion and lesions of DRN increased the sodium appetite response, in basal conditions, after sodium depletion and hypovolemia or after beta-adrenergic stimulation as well. These observations raised the hypothesis that the suppression of ascending pathways from the DRN, possibly, 5-HTergic fibers, modifies the angiotensinergic or sodium sensing mechanisms of the subfornical organ involved in the control of the sodium appetite. 5-HTergic blockade in LPBN induced to similar results, particularly those regarded to the natriorexigenic response evoked by volume depletion or increase of the hypertonic saline ingestion induced by brain angiotensinergic stimulation. In conclusion, many evidences lead to acceptation of an integrated participation resulting of an interaction, between DRN and LPBN, for the sodium appetite control.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200009
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652007000200009
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.79 n.2 2007
Fonte: | info:eu-repo/semantics/openAccess