Data/hora: 04/06/2024 05:36:04

Provedor de dados: | 42
País: | Brazil
Título: | Time course of echocardiographic and electrocardiographic parameters in myocardial infarct in rats
Autores: | Miranda,Amarildo; Costa-e-Sousa,Ricardo H.; Werneck-de-Castro,João P.S.; Mattos,Elisabete C.; Olivares,Emerson L.; Ribeiro,Vanessa P.; Silva,Márcia G.; Goldenberg,Regina C.S.; Campos-de-Carvalho,Antônio C.
Data: | 2007-12-01
Ano: | 2007
Palavras-chave: | Myocardial infarction; Rats; Electrocardiogram; Echocardiogram; Infarct size.
Resumo: | In animal models the evaluation of myocardial infarct size in vivo and its relation to the actual lesion found post mortem is still a challenge. The purpose of the current study was to address if the conventional electrocardiogram (ECG) and/or echocardiogram (ECHO) could be used to adequately predict the size of the infarct in rats. Wistar rats were infarcted by left coronary ligation and then ECG, ECHO and histopathology were performed at 1, 7 and 28 days after surgery. Correlation between infarct size by histology and Q wave amplitude in lead L1 was only found when ECGs were performed one day post-surgery. Left ventricular diastolic and systolic dimensions correlated with infarct size by ECHO on day 7 post-infarction. On days 7 and 28 post-infarction, ejection indexes estimated by M-mode also correlated with infarct size. In summary we show that conventional ECG and ECHO methods can be used to estimate infarct size in rats. Our data suggest that the 7-day interval is actually the most accurate for estimation of infarct size by ECHO.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400006
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652007000400006
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.79 n.4 2007
Fonte: | info:eu-repo/semantics/openAccess