Data/hora: 01/06/2024 16:44:20

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae)	
Autores: 	CUNICO,MIRIAM M.; TREBIEN,HERBERT A.; GALETTI,FÁBIO C.; MIGUEL,OBDULIO G.; MIGUEL,MARILIS D.; AUER,CELSO G.; SILVA,CÉLIO L.; SOUZA,ANA OLÍVIA DE.	
Data: 	2015-12-01	
Ano: 	2015	
Palavras-chave: 	Analgesic; Anesthetic; Antimycobacterial; Ottonia martiana; Piperaceae; Piperovatine.	
Resumo: 	ABSTRACT Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF, DF, and piperovatine showed a potential antimycobacterial effect with MICs of 16.0, 62.0, 62.0 and 8.0 μg/mL, respectively. Piperovatine was more effective than the EE or the other fractions. The selectivity index (SI=IC50/MIC) values calculated for EE, HF, DF and piperovatine based on the MICs and the cytotoxicity against J774 macrophages (IC50 by MTT assay) revealed values of 6.43, 2.34, 1.5 and 9.66, respectively.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000501991	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201520140090	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.87 n.4 2015	
Fonte: 	info:eu-repo/semantics/openAccess