Data/hora: 14/06/2024 02:42:47

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Recent Advances and Perspectives in Cancer Drug Design	
Autores: 	MAGALHAES,LUMA G.; FERREIRA,LEONARDO L.G.; ANDRICOPULO,ADRIANO D.	
Data: 	2018-01-01	
Ano: 	2018	
Palavras-chave: 	Cancer; Targeted therapy; Cytotoxic therapy; Drug discovery.	
Resumo: 	ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and antibody-small molecule conjugates have emerged as a worthwhile approach to improve drug selectivity and reduce adverse effects, which are the main challenges in cancer drug discovery. This review will examine the current panorama of drug research and development (R&amp;D) with emphasis on some of the major advances brought to clinical trials and to the market in the past five years. Breakthrough discoveries will be highlighted along with the medicinal chemistry strategies used throughout the discovery process. In addition, this review will provide perspectives and updates on the discovery of novel molecular targets as well as drugs with innovative mechanisms of action.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301233	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201820170823	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.90 n.1 suppl.2 2018	
Fonte: 	info:eu-repo/semantics/openAccess