Data/hora: 04/06/2024 05:45:37

Provedor de dados: | 42
País: | Brazil
Título: | Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens
Autores: | Leandro,Luís F.; Mendes,Carlos A.; Casemiro,Luciana A.; Vinholis,Adriana H.C.; Cunha,Wilson R.; Almeida,Rosana de; Martins,Carlos H.G.
Data: | 2015-03-01
Ano: | 2015
Palavras-chave: | Antibacterial activity; Apitoxin; Melittin; Phospholipase A2; Tooth decay; Oral pathogens.
Resumo: | In this work, we used the Minimum Inhibitory Concentration (MIC) technique to evaluate the antibacterial potential of the apitoxin produced by Apis mellifera bees against the causative agents of tooth decay. Apitoxin was assayed in naturaand in the commercially available form. The antibacterial actions of the main components of this apitoxin, phospholipase A2, and melittin were also assessed, alone and in combination. The following bacteria were tested: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis, Lactobacillus casei, and Enterococcus faecalis. The MIC results obtained for the commercially available apitoxin and for the apitoxin in natura were close and lay between 20 and 40µg / mL, which indicated good antibacterial activity. Melittin was the most active component in apitoxin; it displayed very promising MIC values, from 4 to 40µg / mL. Phospholipase A2 presented MIC values higher than 400µg / mL. Association of mellitin with phospholipase A2 yielded MIC values ranging between 6 and 80µg / mL. Considering that tooth decay affects people's health, apitoxin and its component melittin have potential application against oral pathogens.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100147
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201520130511
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.87 n.1 2015
Fonte: | info:eu-repo/semantics/openAccess