Data/hora: 11/06/2024 08:27:37

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters	
Autores: 	Kanashiro,Alexandre; Andrade,Daiani C.O.; Kabeya,Luciana M.; Turato,Walter M.; Faccioli,Lucia H.; Uyemura,Sérgio A.; Lucisano-Valim,Yara M.	
Data: 	2009-03-01	
Ano: 	2009	
Palavras-chave: 	Rutin; Golden Syrian hamster; Hypercholesterolemia; Atherosclerosis; Apoptosis; Dimorphandra mollis.	
Resumo: 	Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652009000100009	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.81 n.1 2009	
Fonte: 	info:eu-repo/semantics/openAccess