Data/hora: 13/06/2024 01:03:24

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Expanding the knowledge of the chemical structure of glycoconjugates from Trypanosoma cruzi TcI genotype. Contribution to taxonomic studies	
Autores: 	FONSECA,LEONARDO M.; GARCEZ,TATIANA C.; PENHA,LUCIANA; FREIRE-DE-LIMA,LEONARDO; MAES,EMMANUEL; COSTA,KELLI M.; MENDONÇA-PREVIATO,LUCIA; PREVIATO,JOSE O.	
Data: 	2016-09-01	
Ano: 	2016	
Palavras-chave: 	T. cruzi; Glycans; Mucins; Glycoinositolphospholipids.	
Resumo: 	ABSTRACT One of the main obstacles to the treatment of Chagas disease is the genetic and phenotypical variance displayed by T. cruzi strains, resulting in differences in morphology, virulence, pathogenicity and drug susceptibility. To better understand the role of glycoconjungates in Chagas disease, we performed the molecular characterization of the O-linked chains from mucins and glycoinositolphospholipids (GIPLs) of the Silvio X10 clone 1 strain. We demonstrated the presence of a β-galactofuranose (β-Galf) unity linked to the O-4 position of the α-N-acetylglucosamine (α-GlcNAc)O-4 in Tc-mucins. GIPLs analysis showed that the lipidic portion is exclusively composed of ceramide and the PI-oligossacharidic portion contains the Man4(AEP)GlcN-Ins-PO4 core, substituted by ethanolamine-phosphate (EtNP) on the third distal mannose from inositol, which may or may not have a terminal β Galf unity. These results confirm the classification of the Silvio X10/1 strain in group T. cruzi I. Again, it is noted that the study of T. cruzi surface glycoconjugates confirm the molecular results and the hypothesis that surface glycoconjugates may be interesting biomarker for the differentiation of trypanosomatid strains.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401519	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201620160386	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.88 n.3 2016	
Fonte: 	info:eu-repo/semantics/openAccess