Data/hora: 10/06/2024 08:14:55

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Jabuticaba (Plinia jaboticaba) skin extracts as inhibitors of phospholipases A2 and proteases	
Autores: 	MARQUES,TAMARA R.; BRAGA,MARIANA A.; CESAR,PEDRO H.S.; MARCUSSI,SILVANA; CORRÊA,ANGELITA D.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	Agro-industrial waste; Phenolic compounds; Venom enzymes as laboratory tools; Clotting; Thrombolysis.	
Resumo: 	Abstract: The phenolic extracts of jabuticaba skin flour (JSF) were characterized by HPLC, and evaluated for their modulating action upon phospholipases A2 and proteases of snake venom, aiming at their possible use in the treatment of the various diseases associated with the action of venom toxins. Two types of extracts were prepared from JSF: aqueous and methanolic. These extracts, evaluated at different ratios, (venom: extract, m/m), significantly inhibited the phospholipase activity induced by the venom of Bothrops moojeni and Crotalus durissus terrificus, except for Bothrops atrox venom. The greatest hemolysis inhibitory action was observed for the methanolic extract, when incubated with venoms of B. moojeni and C. durissus terrificus, with inhibitions between 21 and 100%. Thrombolysis induced by venoms of B. moojeni and C. durissus terrificus was inhibited by both extracts, ranging from 32 to 83% and 51 to 83% for the aqueous and methanolic extracts, respectively. Both extracts extended coagulation time, induced by the venoms of B. moojeni and Lachesis muta muta. Inhibitory actions are related to phenolic compounds, such as gallic, syringic and p-coumaric acids, besides catechin, epigallocatechin gallate, epicatechin; resveratrol and quercetin, present in the extracts of jabuticaba skin flour, confirming their potential for nutraceutical use.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300613	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201920180248	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.91 n.2 2019	
Fonte: 	info:eu-repo/semantics/openAccess