Data/hora: 11/06/2024 02:40:14

Provedor de dados: | Anais da Academia Brasileira de Ciências
País: | Brazil
Título: | Interactions between cationic liposomes and drugs or biomolecules
Autores: | CARMONA-RIBEIRO,ANA MARIA.
Data: | 2000-03-01
Ano: | 2000
Palavras-chave: | Interactions; Dioctadecyldimethylammonium bromide; Phospholipids; Liposomes; Drugs; Surfaces.
Resumo: | Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide (DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in the cationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteria and fungi at concentrations that barely affect mammalian cells in culture. Silica particles or polystyrene microspheres can be functionalized by coverage with DODAB bilayers or phospholipid monolayers. Negatively charged antigenic proteins can be carried by the cationic liposomes which generate a remarkable immunoadjuvant action. Nucleotides or DNA can be physically adsorbed to the cationic liposomes to be transferred to mammalian cells for gene therapy. An overview of the interactions between DODAB vesicles and some biomolecules or drugs clearly points out their versatility for useful applications in a near future.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100005
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652000000100005
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.72 n.1 2000
Fonte: | info:eu-repo/semantics/openAccess