Data/hora: 11/06/2024 08:08:02

Provedor de dados: | 42
País: | Brazil
Título: | Genetic drift in mammals
Autores: | BACH,JEAN-FRANÇOIS.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Genetic drift; Genome of populations; De novo mutations; Inbred mouse strains.
Resumo: | Abstract: Genetic drift is the fortuitous occurrence of genetic events that when they become fixed modify the genome of populations. They can take the form of mutations of single nucleotides (SNPs), the insertion or deletion of short sequences (Indels) or the repetitions of short sequences (CNV i.e. copy number variants) or long insertions or deletion (structural modifications). Their frequency is 10-9 to 10-8 depending on the species, or 50 to 100 per birth in humans. The incidence of these de novo mutations is higher when the father is old at conception. It thus appears that genetic drift, which constitutes the initial element of evolution, has a very strong dynamics. Its intervention in the appearance or disappearance of some major phenotypes is complicated by the uncertainties about the genetic mechanisms in heritability which, paradoxically, are only partially understood.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000600613
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201920190339
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.91 suppl.3 2019
Fonte: | info:eu-repo/semantics/openAccess