Data/hora: 10/06/2024 09:15:37

Provedor de dados: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia
País: | Brazil
Título: | Comparative study of the sedative and antinociceptive effects of levomepromazine, azaperone and midazolam in laboratory animals
Autores: | Mataqueiro,M.I.; D’Angelis,F.H.F.; De-Caroli-Neto,A.; Rossi,C.A.; Queiroz-Neto,A.
Data: | 2004-06-01
Ano: | 2004
Palavras-chave: | Sedation; Nociception; Levomepromazine; Azaperone; Midazolam.
Resumo: | The sedative and antinociceptive effects of levomepromazine, azaperone and midazolam were studied in rats and mice using three behavior evaluation methods. Both exploratory behavior and spontaneous locomotor activity were significantly diminished in a spontaneous locomotor activity test in open field when using levomepromazine and azaperone. However, the azaperone effects were short lived in comparison to levomepromazine effects. Midazolam caused reduction in exploratory activity with no effect in spontaneous locomotion. When assessing the antinociceptive effect in the tail flick reflex latency test after infliction of a pain stimulus in rats, tested drugs did not show any antinociceptive effect. The drugs studied were able to abolish the writhing reflex in mice when compared to control. Levomepromazine, azaperone and midazolam, at the doses were able to inhibit the exploratory behavior in rats, proving their sedative effect. Regarding the antinociceptive effects for visceral pain, these drugs were able to block contortions in mice.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000300009
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária
Relação: | 10.1590/S0102-09352004000300009
Formato: | text/html
Fonte: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia  v.56 n.3 2004
Fonte: | info:eu-repo/semantics/openAccess