Data/hora: 16/06/2024 11:01:11

Provedor de dados: | 47
País: | Argentina
Título: | CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Autores: | Zhou,Liping; Guo,Xiaolin; Ba,Jing; Zhao,Lianshuang.
Data: | 2010-08-01
Ano: | 2010
Palavras-chave: | Cell migration; Lamellipodia formation; Uropod formation; Hyaluronic acid.
Resumo: | CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200005
Editor: | Sociedad Latinoamericana de Microscopía Electrónica.; Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina)
Formato: | text/html
Fonte: | Biocell  v.34 n.2 2010
Fonte: | info:eu-repo/semantics/openAccess