Data/hora: 07/06/2024 11:19:18

Provedor de dados: | 48
País: | Chile
Título: | Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult &amp;amp; Schult f. (Bromeliaceae) in rodents
Autores: | Moraes de Carvalho,Katharinne I; Fernandes,Hélio B; Frota Machado,Flávia D; Oliveira,Irisdalva S; Oliveira,Francisco A; Nunes,Paulo Humberto M; Lima,Julianeli T; Silva Almeida,Jackson R G; Meneses Oliveira,Rita C.
Data: | 2010-01-01
Ano: | 2010
Palavras-chave: | Antioxidant; Antiulcer activity; Encholirium spectabile; Bromeliaceae.
Resumo: | This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400011
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.43 n.4 2010