Data/hora: 04/06/2024 13:28:04

Provedor de dados: 	48	
País: 	Chile	
Título: 	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion	
Autores: 	GALARCE,GLORIA D; FONCEA,ROCÍO E; EDWARDS,ANA M; PESSOA-MAHANA,HERNÁN; PESSOA-MAHANA,CARLOS D; EBENSPERGER,ROBERTO A.	
Data: 	2008-01-01	
Ano: 	2008	
Palavras-chave: 	Anti-inflammatory agents; Benzimidazoquinazoline derivatives; TNF-á inhibitors.	
Resumo: 	This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.41 n.1 2008