Data/hora: 10/06/2024 11:01:30

Provedor de dados: | 48
País: | Chile
Título: | Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Autores: | Ramírez,Omar A; Härtel,Steffen; Couve,Andrés.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Endoplasmic reticulum; Protein trafficking; Dendrites; Neuron.
Resumo: | Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.44 n.1 2011