Data/hora: 08/06/2024 02:03:54

Provedor de dados: | Biological Research
País: | Chile
Título: | Carotid body (Thermoreceptors, sympathetic neural activation, and cardiometabolic disease
Autores: | Iturriaga,Rodrigo; Del Rio,Rodrigo; Idiaquez,Juan; Somers,Virend K.
Data: | 2016-01-01
Ano: | 2016
Palavras-chave: | Autonomic dysfunction; Carotid body; Heart failure; Metabolic syndrome; Obstructive sleep apnea; Sympathetic activation.
Resumo: | The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100013
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.49 2016