Data/hora: 04/06/2024 04:29:11

Provedor de dados: | Biological Research
País: | Chile
Título: | IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Autores: | Ávalos,Ana María; Apablaza,Felipe A; Quiroz,Mariana; Toledo,Viviana; Peña,Juan Pedro; Michea,Luis; Irarrazabal,Carlos E; Carrión,Flavio A; Figueroa,Fernando E.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | Interleukin-17; Th17; Myocardial infarction; Cardiovascular disease.
Resumo: | Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-&amp;#946; mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-&amp;#946; mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinflammatory pathway might play a role in early stages of post MI cardiac remodelling.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.45 n.2 2012