Data/hora: 04/06/2024 16:40:09

Provedor de dados: | 48
País: | Chile
Título: | Regional density of glial cells in the rat corpus callosum
Autores: | Reyes-Haro,Daniel; Mora-Loyola,Ernesto; Soria-Ortiz,Berenice; García-Colunga,Jesús.
Data: | 2013-01-01
Ano: | 2013
Palavras-chave: | Astrocytes; Corpus callosum; Genu; Glial cells; Splenium.
Resumo: | Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of axons have been previously described. Whether glial cell density varies accordingly is unknown; thus the aim of this study was to estimate glial cell density for the genu, body and splenium -the three main regions of CC-, of P6 and P30 rats. Here we report that the density of CC glial cells reduced by ~10% from P6 to P30. Even so, the density of astrocytes showed a slight increase (+6%), probably due to differentiation of glioblasts. Interestingly, glial cell density decreased for the genu (-21%) and the body (-13%), while for the splenium a minor increase (+5%) was observed. The astrocyte/glia ratio increased (from P6 to P30) for the genu (+27%), body (+17%) and splenium (+4%). Together, our results showed regional differences in glial cell density of the CC. Whether this pattern is modified in some neuropathologies remains to be explored.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100004
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.46 n.1 2013