Data/hora: 17/06/2024 16:38:00

Provedor de dados: 	48	
País: 	Chile	
Título: 	Toll-like Receptors are Key Participants in Innate Immune Responses	
Autores: 	ARANCIBIA,SERGIO A; BELTRÁN,CAROLL J; AGUIRRE,ISABEL M; SILVA,PAULINA; PERALTA,ALEXIS L; MALINARICH,FRANO; HERMOSO,MARCELA A.	
Data: 	2007-01-01	
Ano: 	2007	
Palavras-chave: 	Toll-like receptors; Innate Immunity; Cytokines; MyD88; NFkB.	
Resumo: 	During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article	
Tipo: 	Journal article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001	
Editor: 	Sociedad de Biología de Chile	
Formato: 	text/html	
Fonte: 	Biological Research  v.40 n.2 2007