Data/hora: 10/06/2024 12:08:43

Provedor de dados: | Biological Research
País: | Chile
Título: | Membrane effects of Cocoa Procyanidins in Liposomes and Jurkat T Cells
Autores: | VERSTRAETEN,SANDRA V.; OTEIZA,PATRICIA I.; FRAGA,CÉSAR G.
Data: | 2004-01-01
Ano: | 2004
Palavras-chave: | Epicatechin; Free radicals; Lipid oxidation; Membrane fluidity; Membrane permeability; Procyanidins.
Resumo: | We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe2+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200016
Editor: | Sociedad de Biología de Chile
Formato: | text/html
Fonte: | Biological Research  v.37 n.2 2004